Barbara Biondi

EDUCATION 1992 Degree in Chemistry, Department of Organic Chemistry, University of Padova, Italy.

CURRENT POSITION

2021 Researcher at CNR, Institute of Biomolecular Chemistry, Padova Unit, Padova, Italy.

INSTITUTIONAL RESPONSIBILITIES

2019 to date: Advisory Committee, Institute of Biomolecular Chemistry 2010 to date: Treasurer (Economo), Institute of Biomolecular Chemistry.

TEACHING ACTIVITIES

2011 to date: Organic and Bioorganic Chemistry, degree course in Biotechnology, University of Padova 2001 to date: supervision of undergraduate and PhD students.

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

Member of the ACS, APS, EPS, SCI, ItPS.

SCIENTIFIC INTERESTS focus on peptides containing non-proteinogenic amino acids to explore their antimicrobial / antitumor activity and to study the mechanisms of interaction with biological membranes. Another relevant focus is the synthesis and conformational analysis of peptides with a rigid and well-defined three-dimensional structure to be used as spacers and templates.

The research activities are aimed at: i) understanding the structure/function relationship in bioactive peptides with antimicrobial and anticancer activities ii) elucidating the charge/electron transfer processes in proteins by use of model peptides with well-defined 3D-structure.

1. Biondi, B.; Cardena, R.; Bisello, A.; Schiesari, R.; Cerveson, L.; Facci, M.; Rancan, M.; Formaggio, F.; Santi, S., Flat, Ferrocenyl-Conjugated Peptides: A Combined Electrochemical and Spectroscopic Study. ChemElectroChem (2021) 8, 2693-2700.

2. Guryanov, I.; Korzhikov-Vlakh, V.; Bhattacharya, M.; Biondi, B.; Masiero, G.; Formaggio, F.; Tennikova, T.; Urtti, A., Conformationally Constrained Peptides with High Affinity to the Vascular Endothelial Growth Factor. J. Med. Chem. (2021) 64, 10900-10907.

3. Golysheva, E. A.; Boyle, A. L.; Biondi, B.; Ruzza, P.; Kros, A.; Raap, J.; Toniolo, C.; Formaggio, F.; Dzuba, S. A., Probing the E/K Peptide Coiled-Coil Assembly by Double Electron–Electron Resonance and Circular Dichroism. Biochemistry (2021) 60, 19-30.

4. Kubitzky, S.; Venanzi, M.; Biondi, B.; Lettieri, R.; De Zotti, M.; Gatto, E., A pH-Induced Reversible Conformational Switch Able to Control the Photocurrent Efficiency in a Peptide Supramolecular System. Chem.-Eur. J. (2021) 27, 2810-2817.

5. Santi, S.; Bisello, A.; Cardena, R.; Tomelleri, S.; Schiesari, R.; Biondi, B.; Crisma, M.; Formaggio, F., Flat, Cα,β-Didehydroalanine Foldamers with Ferrocene Pendants: Assessing the Role of α-Peptide Dipolar Moments. ChemPlusChem (2021) 86, 723-730.