Fausta Ulgheri

Dr. Fausta Ulgheri graduated in Chemistry (Organic Chemistry) at the Faculty of Sciences at the University of Sassari (Italy) with the thesis “Total Synthesis of Indolizidine Alkaloids” (Journal Chem. Soc. Perkin Trans. I, 1993, 2991-2997), under the supervision of Prof. Giovanni Casiraghi. After a post-graduate experience in Italy and abroad working on the design and synthesis of new bioactive molecules, in December 2001 she became a permanent researcher at the CNR-Institute of Biomolecular Chemistry in Sassari in the Department of Chemical Sciences and Materials Technologies.

Her research activity is focused on the development of new synthetic green protocols and on the study, design, and synthesis of new biologically active molecules.

In particular recently:

Design and synthesis of PROTACS as antivirals agents against SARS-CoV-2.

Design and synthesis of non-covalent and non-peptidic inhibitors of caspase-1, for the treatment of dysregulated immune response in neurodegenerative diseases, cancer and in SARS-CoV-2 induced multisystemic inflammation.

Synthesis of Telomerase’s inhibitors as anticancer agents.

1) F. Ulgheri, P. Spanu, F. Deligia, G. Loriga, M. P. Fuggetta, I. de Haan, A. Chandgudge, M. Groves, A. Domling, Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders, European Journal of Medicinal Chemistry, 2021, in press accepted for publication doi.org/10.1016/j.ejmech.2021.114002.

2) P. Spanu, MP. Fuggetta, F. Ulgheri, F. Deligia, P. Carta, A. Mannu, V. Trotta, R. De Cicco, A. Barra, E. Zona, F.Morelli; A new synthetic spiroketal: studies on antitumor activity on murine melanoma model In vivo and mechanism of action In vitro, Anticancer Agents in Medicinal Chemistry 2019, 4, 567-578.

3) Fuggetta, M. P.; De Mico, A.; Cottarelli, A.; Morelli, F.; Zonfrillo, M.; Ulgheri, F.; Peluso, P.; Mannu, A.; Deligia, F.; Marchetti, M.; Roviello, G., Reyes Romero, A.; Dömling, A.; Spanu, P. Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity, J. Med. Chem. 2016, 59, 9140−9149.

4) M. Marchetti, S. Paganelli, D. Carboni, Fausta Ulgheri, G. Del Ponte, Synthesis of Indole Derivatives by Domino Hydroformilation/Indolazion of 2-Nitrocinnamaldheydes, Journal of Molecular Catalysis A: Chemical, 2008, 288, 103.

5) Fausta Ulgheri, Mauro Marchetti, Oreste Piccolo, Enantioselective Synthesis of (S)- and (R)-Tolterodine by Asymmetric Hydrogenation of a Coumarin Derivative Obtained by a Heck Reaction, Journal of Organic Chemistry, 2007, 72, 6056.