Grazia Palomba

Degree in Chemistry and PhD in Biochemistry, Biology and Molecular Biotechnology from the University of Sassari.

National qualification to the practise of the profession of Chemist .

National Scientific Habilitation by the Italian Ministry of University Education (MIUR) for a Professor (Seconda Fascia) in S.C. 05/E3 – BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA.

Full Researcher at ICB-CNR (Institute of biomolecular chemistry)

His research activity concerning cancer genetics and in particular melanoma, breast cancer and colorectal cancer.

Technical skills: Experience on the main Molecular Biology techniques (PCR, RT-PCR, NGS Sequencing, DNA and RNA extraction from whole blood samples, and from tumor tissue. Experience in cell cultures. Experience on fixation and immunohistochemical labeling procedures with specific antibodies and the analysis of preparations under fluorescence microscopy.

Genetic database management.

He has been engaged as a participant in several research projects including:

Airc projct: Epigenetic modeling/remodeling of cancer metastases and tumor immune contexture to improve efficacy of immunotherapy;

Convention with con: Azienda Ospedaliero Universitaria (AOU) di Sassari: Analisi diagnostiche di mutazioni geniche su tessuti tumorali

• Palmieri G, Paliogiannis P, Sini MC, Manca A, Palomba G, Doneddu V, Tanda F, Pascale MR, Cossu A. Long non-coding RNA CASC2 in human cancer. Crit Rev Oncol Hematol. 2017 Mar;111:31-38. doi: 10.1016/j.critrevonc.2017.01.003. Epub 2017 Jan 12. PMID: 28259293.

https://pubmed.ncbi.nlm.nih.gov/28259293/

• Palomba G, Doneddu V, Cossu A, Paliogiannis P, Manca A, Casula M, Colombino M, Lanzillo A, Defraia E, Pazzola A, Sanna G, Putzu C, Ortu S, Scartozzi M, Ionta MT, Baldino G, Sarobba G, Capelli F, Sedda T, Virdis L, Barca M, Gramignano G, Budroni M, Tanda F, Palmieri G. Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study. J Transl Med. 2016 Oct 13;14(1):292. doi: 10.1186/s12967-016-1053-z. PMID: 27737711; PMCID: PMC5064898.

https://pubmed.ncbi.nlm.nih.gov/27737711/

• Palomba G, Atzori F, Budroni M, Ombra M, Cossu A, Sini M, Pusceddu V, Massidda B, Frau B, Notari F, Ionta M, Palmieri G. ERCC1 polymorphisms as prognostic markers in T4 breast cancer patients treated with platinum-based chemotherapy. J Transl Med. 2014 Sep 25;12:272. doi: 10.1186/s12967-014-0272-4. PMID: 25253066; PMCID: PMC4177579.

https://pubmed.ncbi.nlm.nih.gov/25253066/

• Palomba G, Colombino M, Contu A, Massidda B, Baldino G, Pazzola A, Ionta M, Capelli F, Trova V, Sedda T, Sanna G, Tanda F, Budroni M; Sardinian Translational Oncology Group (STOG), Palmieri G, Cossu A, Contu M, Cuccu A, Farris A, Macciò A, Mameli G, Olmeo N, Ortu S, Petretto E, Pusceddu V, Virdis L. Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia. J Transl Med. 2012 Aug 29;10:178. doi: 10.1186/1479-5876-10-178. PMID: 22931052; PMCID: PMC3480926.

https://pubmed.ncbi.nlm.nih.gov/22931052/

• Palomba G, Pisano M, Cossu A, Budroni M, Dedola MF, Farris A, Contu A, Baldinu P, Tanda F, Palmieri G. Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian patients with breast carcinoma through hospital-based screening. Cancer. 2005 Sep 15;104(6):1172-9. doi: 10.1002/cncr.21298. PMID: 16047344.

https://pubmed.ncbi.nlm.nih.gov/16047344/