Descrizione:
Alzheimer’s disease (AD) is the sixth leading cause of disability due to its high incidence and represents a huge health and social problem. AD involves various pathological events, including accumulation in the brain of beta-amyloid protein (Aβ) aggregates responsible for triggering oxidative stress, synaptic degeneration, and neuronal death. Furthermore, increasing evidence posits that AD pathogenesis involves strong interactions with immunological mechanisms in the brain.
Obiettivo del progetto:
The commitment of the research network is to create new multifunctional hybrid bio-conjugates, where the biochemical activity of the metal compounds or of the NPs will be boosted by a peptide-based upgrade.
Coordinatore e personale coinvolto:
TMauro Carraro (PI, UNIPD)
CNR Unit: Paolo Ruzza (coordinatore), Giovanni Loriga
Ente capofila:
UNIPD
Enti partecipanti:
UNIPD, UNIBO
