Giuseppe Granata

EDUCATIONAL QUALIFICATIONS

Ph.D. in Chemical Sciences on 04/03/2005 at the University of Catania.

Degree in Chemistry (specialization in Biomolecular Chemistry) on 07/12/2000 at the University of Catania.

RESEARCH ACTIVITIES

• May 2014 – currently Researcher at C.N.R. – Institute of Biomolecular Chemistry – branch of Catania (Permanent Researcher since 30 November 2018).

His research is mainly focused on the field of Organic and Bioorganic Chemistry and Supramolecular Chemistry:

• Design and preparation of calixarene derivatives, their characterization and molecular properties, study of their assembling and biomolecular recognition capabilities.

• Design and preparation of biocompatible and amphiphilic constructs based on calixarene macrocycles, development of physico-chemical protocols for the aggregation of these constructs in nanostructured systems (such as drug nanocontainers, nanocarriers, etc.) and characterization of the nanosystems (size, Z potential, drug loading, etc.).

And in the Agri-Food sector:

• Realization and characterization of nanostructured systems (biocompatible and biodegradable nanoparticles) containing active ingredients of nutritional and biological interest.

• Analytical studies, such as the determination of antioxidant activity, total amount of polyphenols, and individual components.

1. G. Granata, S. Petralia, G. Forte, S. Conoci, G. M. L. Consoli. “Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4]arene derivative and curcumin for a sustained drug release”. Materials Science and Engineering C, 2020, 111, 110842.

2. G. Granata, S. Stracquadanio, M. Leonardi, E. Napoli, G. M. L. Consoli, V. Cafiso, S. Stefani, C. Geraci “Essential oils encapsulated in polymer–based nanocapsules as potential candidates for application in food preservation”. Food Chemistry 2018, 269, 286–292.

3. G. Granata, G. M. L. Consoli, R. Lo Nigro, C. Geraci. “Hydroxycinnamic acids loaded in lipid-core nanocapsules”. Food Chemistry 2018, 245, 551–556.

4. G. Granata, I. Paterniti, C. Geraci, F. Cunsolo, E. Esposito, M. Cordaro, A. R. Blanco, S. Cuzzocrea, G. M. L. Consoli. “Potential eye drop based on a calix[4]arene nanoassembly for curcumin delivery: enhanced drug solubility, stability, and antiinflammatory effect”. Mol. Pharmaceutics 2017, 14, 1610−1622.

5. G. M. L. Consoli, G. Granata, G. Fragassi, M. Grossi, M. Sallese, C. Geraci. “Design and synthesis of a multivalent fluorescent folate-calix[4]arene conjugate: cancer cell penetration and intracellular localization”. Org. Biomol. Chem. 2015, 13, 3298–3307.